Idarucizumab dose10/7/2023 Used for urgent reversal of dabigatran anticoagulation in patients with life-threatening or uncontrolled bleeding or need for emergency surgery/urgent procedures designated an orphan drug by FDA for this use. Uses for Idarucizumab Reversal of Dabigatran Anticoagulation ![]() Specific reversal agent for anticoagulant effects of dabigatran recombinant humanized monoclonal antibody fragment capable of binding dabigatran. according to expert consensus, the combination of idarucizumab and IVT is suggested f or patients with acute ischemic stroke of ![]() administration of thrombolysis after prior neutralization of the effect of dabigatran with the antidote PRAXBIND is possible (IVT is an emergency procedure).IVT may be considered in patients with normal TT or TT 6h after the last dose of the drug indicates the absence of anticoagulant activity. ![]() normal aPTT alone is not sufficient it does not completely rule out an elevated TT.intravenous thrombolysis (IVT) in patients with acute ischemic stroke is possible with dabigatran therapy if aPTT + TT, ECT, or HEMOCLOT values do not exceed the upper limits of normal (AHA/ASA 2013 III/C).
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